Item |
Requirements and manufacturers |
Fermenter body |
The size of fermenter takes in general use type as basis and The main material of the fermenter is made by 316Lstainless steel. The design pressure: P(inside)= 0.3Mpa, P(interlayer)= 0.3Mpa, The polishing precision: Ra0.4~0.6, the ratio between diameter and height: 1:2.5 Working volume:30%-70% of total volume |
Sterilization method |
Auto sterilizing in situ (SIP) |
Stirring system |
Mechanical sealing system at the top of the fermenter; high-powered stirring oar, antifoam oar; AC electrical machine(SEW): infinite speed variation; rpm in the 80L germ fermenter: 70~800rpm±1%,The height of the stirring oar can be adjusted, too. |
Temperature detection and control |
Heat by thermostatic water tank and circulate by circulating pump(Grundfos, Denmark), autocontrol (cooling water+5℃)~70℃±0.1℃,temperature probe(imported) |
pH detection and control |
2.00-12.00±0.05pH, autocontrol by adding acid and base, pH sensor (Hamilton /Mettler, Switzerland) and shielding lead (Hamilton / Mettler, Switzerland). 150L fermenter is autocontrolled with peristaltic pump |
Feed control |
Uses peristaltic pump (Longer) to add meterials |
Antifoam control |
Tested by sencor and added antifoamer by peristaltic pump |
Aeration detection and control |
Control ventilatory capacity, the precision of inhaler : 0.1μ, displayed by rotameter. The range of flow adjusting :0~200L/min |
Pressure detection and control |
Auto control exhaust by diaphragm cell valve, and displayed by pressure gauge. And pressure transmitter |
Pipeline and valve |
The pipelines and valves which are in contact with the zymotic fluid are made by 316L stainless steel, the valves are diaphragm cell valves |
Control system |
BLBIO B Control System: on-site controller, the next crew for the Siemens S7-200 series PLC control system, it is a mature, stable, universal type of PLC, to suit a variety of automation applications, especially in manufacturing process control Application. Its modular, easy to implement distributed configuration and easy to master and so on, Siemens PLC control center has become a biological reaction process control implementation is economical and advanced control system, the system uses the touch screen display, on-site direct operations (menu type), all English menu and interface; also with the host computer for data transmission, data sampling and display tank, the system view of data analysis, reading settings. 10-inch LCD touch-sensitive screen as the display screen to display complete content-rich, user-friendly screen is simple, easy to operate. And disturbing each other. The control system can adapt to different range of sensors and actuators the output of the input signal with the signal anti-jamming system. Software: Siemens S7+ FORCE CONTORL Data collection and control module: Siemens S200 PLC controller and data collection and control module 1. Control 2. Measurement function: can feeding, bubble enemy, such as measurement of pH 4. Data Processing 5) data storage format is compatible with EXCEL, EXCEL platform can be to deal with 9. show the controller is really running against, the panel instructed the state process system, process hardware, and motion status indicator for understanding the various devices (such as peristaltic pumps, circulating pumps, heating, mixing, etc.) work status, Fault identification can be used as display |
PC software
|
BLBIO-Ver8.0 is a data recording and processing as one of the fermentation of special packages, with the English operation interface, data storage and backup, curve analysis, report generation analysis, anomaly analysis, for the fermentation and production process control and data processing bring a lot of convenience. 6. Report Printing 7. curve printing |
Technical parameter:
No |
Parameter |
Guideline |
Controller data processing function |
1 |
pH |
Displaying range: 0.00~14.00±0.01 Auto-control range:2.00~12.00±0.05 Fermentation process control (According to the fermentation time, auto- control pH fluent, at least10 parts) |
pH value historical and trend curve analysis Acid, alkali dosage curve analysis Batch report form analysis Acid, alkali total dosage record Keep and deliver data |
3 |
Antifoam |
Automatic PID control and alarm Fermentation process control (According to the fermentation time, auto- control antifoam fluent, at least10 parts) |
Antifoam value historical and trend curve analysis Foam error state record antifoam total dosage record Batch report form analysis Keep and deliver data |
4 |
Rev |
Automatic enactment and control Fermentation process control (According to the fermentation time, auto- control rev fluent, at least10 parts) |
Rev value historical and trend curve analysis Batch report form analysis Keep and deliver data |
5 |
Temperature |
Temperature of cooling water: +5℃-80℃±0.1℃ Fermentation process control (According to the fermentation time, auto- control temperature fluent, at least10 parts) |
Temperature value historical and trend curve analysis Batch report form analysis Keep and deliver data |
6 |
Feeding |
PID automatic enactment and control Fermentation process control (According to the fermentation time, auto- control feeding fluent, at least10 parts) |
Feeding value historical and trend curve analysis Feeding total dosage record Batch report form analysis Keep and deliver data |
7 |
Pressure |
Auto control, |
|
8 |
Air flux |
Auto control, |
|
Material and brand of key components
No. |
Key component |
Material and brand |
1 |
Vessel system |
The cylinder designed by our company uses stainless steel ,lThe framework is advanced. |
2 |
Speed Motor |
Germany SEW |
3 |
Speed regulator |
Germany Siemens |
4 |
Solenoid valve |
German burkert |
5 |
Aeration filter |
0.2μm, Dominica United Kingdom |
6 |
Breathing filter |
0.2μm, SARTORIUS, Germany |
7 |
pH electrode |
Hamilton / Mettler-Toledo, Switzerland |
8 |
DO electrode |
Hamilton /Mettler-Toledo, Switzerland |
9 |
Peristaltic pump |
Lange (United States) |
10 |
PLC |
Siemens Germany |
11 |
LCD touch screen |
GCMS |
12 |
Mechanical seal |
John Crane United Kingdom |
13 |
diaphragm |
Proudly Germany |
14 |
Pressure regulator |
German burkert |
15 |
Thermal mass flowmeter |
German burkert |
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