cTnI Troponin CK-MB Creatine Kinase-MB reagents Cardiac Markers Fast Rapide Test Kits For Ichroma

Intended use

The Myoglobin/CK-MB/Troponin I Rapid Combo Test Device (Whole Blood/Serum/ Plasma) is a rapid chromatographic immunoassay for the qualitative detection of human Myoglobin, CK-MB and cardiacTroponin I in whole blood, serum or plasma as an aid in the diagnosis of myocardial infarction (MI).
Summary

Myoglobin (MYO), Creatine Kinase MB (CK-MB) and cardiac Troponin I (cTnI) are proteins released into the bloodstream after cardiac injury. Myoglobin is a heme-protein normally found in skeletal and cardiac muscle with a molecular weight of 17.8 kDa. It constitutes about 2 percent of total muscle protein and is responsible for transporting oxygen within muscle cells.1 When muscle cells are damaged, Myoglobin is released into the blood rapidly due to its relatively small size. The level of Myoglobin increases measurably above baseline within 2-4 hours post-infarct, peaking at 9-12 hours, and returning to baseline within 24-36 hours.2,3 CK-MB is an enzyme also present in the cardiac muscle, with a molecular weight of 87.0 kDa.4 Creatine Kinase is a dimeric molecule formed from two subunits designated as “M” and “B”, which combine to form three different isoenzymes, CK-MM, CK-BB nd CK-MB. CK-MB is the isoenzyme of Creatine Kinase most involved in the metabolism of cardiac muscle tissue.5 The release of K-MB into the blood
following an MI can be detected within 3-8 hours after the onset of symptoms. It peaks within 9 to 30 hours, and returns to baseline n levels within 48 to 72 hours.6 Cardiac Troponin I is a protein found in cardiac muscle, with a molecular weight of 22.5 kDa.7 Troponin I is part of a three subunit complex comprised of Troponin T and Troponin C. Along with tropomyosin, this structural complex forms the main component that regulates the calcium sensitive ATPase activity of actomyosin in striated skeletal and cardiac muscle.8 After cardiac injury occurs, Troponin I is released into the blood 4-6 hours after the onset of pain. The release pattern of Troponin I is similar to CK-MB, but while CK-MB levels return to normal after 72 hours, Troponin I remains elevated for 6-10 days, thus providing for a longer window of detection for cardiac injury. The Myoglobin/CK-MB/Troponin I Rapid Combo Test Device (Whole Blood/Serum/ Plasma) utilizes a combination of antibody coated particles and capture reagents to qualitatively detect Myoglobin CK-MB and Troponin I in whole blood, serum or plasma. The minimum detection level is 50 ng/mL Myoglobin, 5 ng/mL CK-MB and 0.5 ng/mL Troponin I.

GEMC is the short name of Gem Medic Electric & Technology Co.,Ltd located in Henan Province, China, which is a privately-held corporation high-tech enterprise specializing in trade of rapid medic diagnostic test kits and device. The main products we supply are pregnancy test kits, ovulation test kits, sperm fertility test, drug of abuse test, infectious disease test, saliva alcohol tester, digital clinical thermometer, blood pressure monitor,ovulation microscope monitor and other medical test device.

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