Ginsenoside rg3 Ginsenoside rh2 Extract Panax Ginseng
Ginsenoside rg3 Ginsenoside rh2 Extract Panax Ginseng
| Biological effects | |||||||||||||||
| Most studies of the biological effects of ginsenosides have been in cell culture or animal models and thus their relevance to human biology is unknown. Effects on the cardiovascular system, the central nervous system, the immune system have been reported, primarily in rodents. Antiproliferative effects have also been described.[1][8] | |||||||||||||||
| Many studies suggest that ginsenosides have antioxidant properties. Ginsenosides have been observed to increase internal antioxidant enzymes and act as a free-radical scavenger.[5] Ginsenosides Rg3 and Rh2 have been observed in cell models as having an inhibitory effect on the cell growth of various cancer cells while studies in animal models have suggested that ginsenosides have neuroprotective properties and could be useful in treating neurodegenerative disease such as Alzheimer's and Parkinson's diseases.[5] | |||||||||||||||
| Two broad mechanisms of action have been suggested for ginsenoside activity, based on their similarity to steroid hormones. They are amphiphilic and may interact with and change the properties of cell membranes.[1] Some ginsenosides have also been shown to be partial agonists of steroid hormone receptors. It is not known how these mechanisms yield the reported biological effects of ginsenosides. The molecules as a class have low bioavailability due to both metabolism and poor intestinal absorption. | |||||||||||||||
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TDS of ginseng extract
| Product and Batch Information | |||
| Product Name: | Ginseng Extract | Country of Origin: | P.R. China |
| Botanic Name: | Panax Ginseng | Type of extraction: | Water/Grain Alcohol |
| Plant Part: | Leaf and stem (Dried, 100% Natural) | Active Ingredient: | Ginsenosides |
| Batch: | PES80-120405 | Manufacture Date: | April 05,2016. |
| Extract Ratio: | Approx. 120 to 1 extract | Analysis Date: | April 05,2016. |
| Analysis: | 1000Kg | Report Date: | April 12,2016. |
| Analysis Item | Specification | Result | Test Method |
| Active Ingredeints | |||
| Assay | NLT 80% Ginsenosides | 82.12% | UV-VIS |
| Physical Control | |||
| Identification | Positive | Conforms | TLC |
| Appearance | Fine powder | Conforms | Visual |
| Color | Milk yellow | Conforms | Visual |
| Odor | Characteristic | Conforms | Organoleptic |
| Taste | Characteristic | Conforms | Organoleptic |
| Sieve Analysis | 95% pass 80 mesh | Conforms | 80 Mesh Screen |
| Loss on Drying | 7% Max | 4.14% | 5g / 105C /5hrs |
| Ash | 5% Max | 3.56% | 2g / 525C / 5hrs |
| Sterilisation Method | High Temperature & High Pressure for short time (5” – 10”)(Free from Gamma Irradiation). | ||
| GMO Status | GMO Free | Conforms | / |
| Chemical Control | |||
| Arsenic (As) | NMT 2ppm | Conforms | Atomic Absorption |
| Cadmium(Cd) | NMT 1ppm | Conforms | Atomic Absorption |
| Lead (Pb) | NMT 1ppm | Conforms | Atomic Absorption |
| Chlorate (Cl) | NMT 1ppm | Conforms | Atomic Absorption |
| Phosphate Organics | NMT 1ppm | Conforms | Gas Chromatography |
| Heavy Metals | 10ppm Max | Conforms | Atomic Absorption |
| Pesticides Residues | NMT 1ppm | Conforms | Gas Chromatography |
| Microbiological Control | |||
| Total aerobic microbial count | 10000cfu/g Max | Conforms | AOAC |
| Total yeast and mould count | 100cfu/g Max | Conforms | AOAC |
| Bile-tolerant gram negative bacteria | 100cfu/g Max | Conforms | AOAC |
| Salmonella | Absent in 10g | Conforms | AOAC |
| E.Coli | Absent in 1g | Conforms | AOAC |
| Staphylococcus aureus | Absent in 1g | Conforms | AOAC |
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Introduction
Ginseng is any one of the 11 species of slow-growing perennial plants with fleshy roots, belonging to the genus Panax of the family Araliaceae.
Ginseng is found in North America and in eastern Asia (mostly northeast China, Korea, Bhutan, eastern Siberia), typically in cooler climates. Panax vietnamensis, discovered in Vietnam, is the southernmost ginseng known. This article focuses on the species of the series Panax, which are the species claimed to be adaptogens, principally Panax ginseng and P. quinquefolius. Ginseng is characterized by the presence of ginsenosides and gintonin.
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Biosynthesis
The biosynthetic pathway of ginsenosides is not entirely characterized, though as steroids they derive from pathways that lead to the synthesis of isoprene units. A proposed pathway converts squalene to 2,3-oxidosqualene via the action of squalene epoxidase, at which point dammaranes can be synthesized through dammarenediol synthase, oleananes through beta-amyrin synthase, and another class of molecules, the phytosterols, through cycloartenol synthase.[4]
In the proposed pathway, squalene is synthesized from the assembly of two farnesyl diphosphate (FPP) molecules. Each molecule of FPP is in turn the product of two molecules of dimethylallyl diphosphate and two molecules of isopentenyl diphosphate (IPP). IPP is produced by the mevalonic pathway in the cytosol of a ginseng plant cell and by the methylerythritol phosphate pathway in the plant's plastid.[7]
Ginsenosides likely serve as mechanisms for plant defense.[7][8] Ginsenosides have been found to have both antimicrobial and antifungal properties. Ginsenoside molecules are naturally bitter-tasting and discourage insects and other animals from consuming the plant.[7]
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To see the Classification of ginsegn extract ginsenoside,pls click here.
1. ginseng powder is effective for treating colds, coughs, rheumatism, neuralgia, gout, diabetes, anemia insomnia, stress, headache, backache and double vision.
2. ginseng root extract is helpful in normalizing menstruation and easing childbirth.
3. panax ginseng extract against Periodontal Disease which is a progressive destruction of the supporting structures of the teeth.
4. panax ginseng extract powder also counteracts the effects of physical and emotional stress, enhances memory, counteracts fatigue without caffeine, and improves stamina.
5. red ginseng extract stimulates the immune system, by spuring the production of the body's own virus fighting chemicals, helps reduce cholesterol levels in the blood, has anti-clotting effects, reducing risk of arterial blood clots;
6. ginseng extract powder helps control diabetes by reducing blood sugar levels;
7. american ginseng extract is known as an antioxidant, preventing the cumulative cell damage researchers believe cumulates in cancer;
8. 100% soluble in water panax ginseng extract protects the liver from the effects of drug, alcohol and toxins, minimizes cell damage from radiation, and increases intestinal absorption of nutrients.
9,below is the effect of ginsenoside from abstract:
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