Rauvolfia Serpentina Extract, Reserpine is extracted from the root of Rauwolfia serpentina or Rauwolfia vomitoria, plants found in India and Africa. Reserpine initiated the effective pharmacotherapeutic control of hypertension. Reserpine is a naturally occurring drug that has been used for centuries in ancient India. Reserpine reduces the cardiac output by negative isotropic effect and negative chronotropic effect. Similarly by reducing sympathetic activity to blood vessels, Reserpine relaxes capacitance vessels and reduces total peripheral resistance..